Many infections, bacterial, viral, and fungal can arise in the oral cavity and oropharynx. Both common and uncommon diseases will be presented with treatment recommendations. An overview of HPV infections that affect the mouth, the natural history of HPV infection and which HPV-associated lesions are of most concern. The presentation of oropharyngeal carcinoma in contrast to oral cavity cancer will be illustrated and the role of oral health care providers in screening for these cancers will be discussed. The oral changes associated with cigarette, cigar, smokeless tobacco, marijuana, and vaping will be illustrated. Emphasis on the clinical presentation of oral dysplasia or early cancer will be explained.  The instructor will review the proliferative verrucous leukoplakia with an emphasis on management and important clinical distinctions from lichen planus.